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Cheese Tortellini Pepperoni Pizza Casserole Recipe


Cheese Tortellini Pepperoni Pizza Casserole is a delightful and easy-to-make dish that combines the best of pizza and pasta. This casserole features cheese-filled tortellini, tangy pizza sauce, diced tomatoes, and plenty of cheese and pepperoni. It’s perfect for a family dinner or a potluck gathering. In this blog post, we’ll walk you through the ingredients, instructions, and tips for making the perfect Cheese Tortellini Pepperoni Pizza Casserole. Additionally, we’ll provide variations and address frequently asked questions to ensure you achieve the best results.



For the Cheese Tortellini Pepperoni Pizza Casserole:

  • 1 (20 ounce) package of refrigerated cheese tortellini
  • 1 tablespoon olive oil
  • 1 medium onion, chopped
  • 2 cloves garlic, minced
  • 1 (15 ounce) can pizza sauce
  • 1 (14.5 ounce) can diced tomatoes
  • 1 teaspoon dried oregano
  • 1 teaspoon dried basil
  • 2 cups shredded mozzarella cheese
  • 1 cup sliced pepperoni
  • 1/2 cup grated Parmesan cheese
  • Salt and pepper to taste


Step 1: Prepare the Tortellini

  1. Cook Tortellini: Bring a large pot of salted water to a boil. Add the cheese tortellini and cook according to the package instructions until al dente. Drain and set aside.

Step 2: Prepare the Sauce

  1. Heat Olive Oil: In a large skillet, heat the olive oil over medium heat.
  2. Cook Onion and Garlic: Add the chopped onion and cook until softened, about 5 minutes. Add the minced garlic and cook for another 1-2 minutes, until fragrant.
  3. Add Pizza Sauce and Tomatoes: Stir in the pizza sauce and diced tomatoes (with their juice). Add the dried oregano and dried basil. Season with salt and pepper to taste. Let the sauce simmer for about 10 minutes, allowing the flavors to meld together.

Step 3: Assemble the Casserole

  1. Preheat Oven: Preheat your oven to 375°F (190°C).
  2. Combine Tortellini and Sauce: In a large mixing bowl, combine the cooked tortellini with the sauce mixture. Toss until the tortellini are evenly coated.
  3. Layer Ingredients: In a greased 9×13-inch baking dish, spread half of the tortellini mixture. Sprinkle with half of the shredded mozzarella cheese and half of the sliced pepperoni. Repeat with the remaining tortellini mixture, mozzarella cheese, and pepperoni.
  4. Top with Parmesan: Sprinkle the grated Parmesan cheese evenly over the top of the casserole.

Step 4: Bake the Casserole

  1. Bake: Cover the baking dish with aluminum foil and bake in the preheated oven for 20 minutes. Remove the foil and bake for an additional 10-15 minutes, or until the cheese is melted and bubbly, and the casserole is heated through.

Step 5: Serve

  1. Cool Slightly: Allow the casserole to cool for a few minutes before serving.
  2. Serve: Serve the Cheese Tortellini Pepperoni Pizza Casserole hot, garnished with fresh basil or parsley if desired. Enjoy!

Cooking Notes and Variations

Cooking Notes

  • Tortellini: Make sure to cook the tortellini just until al dente, as they will continue to cook in the oven.
  • Pepperoni: You can use mini pepperoni slices for easier layering and distribution.


  1. Vegetarian Option: Omit the pepperoni and add vegetables like bell peppers, mushrooms, or olives for a vegetarian version.
  2. Spicy Kick: Add a pinch of red pepper flakes to the sauce for a spicy twist.
  3. Different Cheeses: Use a blend of cheeses like cheddar, Monterey Jack, or provolone for different flavors.

Frequently Asked Questions (FAQs)

Q1: Can I make this dish ahead of time?

A: Yes, you can assemble the casserole ahead of time and refrigerate it until ready to bake. Add an additional 5-10 minutes to the baking time if baking directly from the refrigerator.


Q2: How do I store leftovers?

A: Store any leftover casserole in an airtight container in the refrigerator for up to 3 days. Reheat in the microwave or oven before serving.

Q3: Can I freeze this casserole?

A: Yes, you can freeze the assembled but unbaked casserole. Wrap it tightly with plastic wrap and aluminum foil and freeze for up to 3 months. Thaw in the refrigerator overnight before baking.

Q4: What can I serve with Cheese Tortellini Pepperoni Pizza Casserole?

A: This casserole pairs well with a simple green salad, garlic bread, or steamed vegetables.

Q5: Can I use homemade pizza sauce?

A: Yes, you can use homemade pizza sauce if you prefer. Adjust the seasoning as needed.

Cheese Tortellini Pepperoni Pizza Casserole is a comforting and delicious dish that’s perfect for any meal. With its combination of cheese-filled tortellini, tangy pizza sauce, and plenty of cheese and pepperoni, it’s sure to be a hit with family and friends. Follow these simple steps and tips to create a tasty and satisfying casserole that everyone will love. Serve this delightful dish with your favorite sides for a complete and hearty meal!

Whether you’re looking for a quick weeknight dinner, a fun potluck dish, or a comforting meal to enjoy with loved ones, this Cheese Tortellini Pepperoni Pizza Casserole is an excellent choice. Enjoy the rich flavors and the ease of preparation, and feel free to experiment with different variations to make this recipe your own.